A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP
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چکیده
منابع مشابه
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).
The Yes-associated protein (YAP) transcription coactivator is a key regulator of organ size and a candidate human oncogene. YAP is inhibited by the Hippo pathway kinase cascade, at least in part via phosphorylation of Ser 127, which results in YAP 14-3-3 binding and cytoplasmic retention. Here we report that YAP is phosphorylated by Lats on all of the five consensus HXRXXS motifs. Phosphorylati...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2010
ISSN: 0890-9369
DOI: 10.1101/gad.1843810